I think Julio’s suggestion may very well be the word you are looking for. Even then, that word "perdida" in Spanish may have various connotations. Perdida could mean lost or disoriented: It may also refer to a girl or woman who lives a wasted life, and finally it may refer to someone who is missing (which is not de case here). I would suggest to your friend telling the rest of the bus riders that if they need to say something about her, she would appreciate their telling it to her face. Straight approach is probably the best cure. They will probably stop making fun of her (if that is indeed what’s going on).
Good luck
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